The Genetic Risk at Every Childbirth:

A rather new approach for those who do not regularly study the genetic and immunoreactive factors by which someone could explain a great number of variations in the final expression of temperament of any individual, as it happens with the difficult child or adult. At the beginning of life was an almost miracle. It could be compared to the Universe Big Bang, in the small infinite world. In a matter of days, weeks, billions of brain cells must develop in harmony, through there a totally invisible fight for life, between the mother and fetus survival.

Everyone knows about RH, ABO blood compatibility factors and how badly the consequences could be in pregnancies when there is one positive and another negative. Reject phenomena's are at hand. Contractions, bleedings, premature births are frequent, with brain suffering and damage already made in the newborn child But compatibility factors are more numerous that usually thought. The fetus is half a foreign body to the mother body and the male "Y" makes thing worse as still another difference. It is well known that the oldest child and more often the boy has more chance of having physical or mental problems. Autism, ADHD are 4-5 times more prevalent in boys than in girls.

Because of the foreign part of father, the embryo is a half a transplant, subjected to a process of immunoreactive reactions from the mother who fights to defend herself from this foreign body. Antibodies are fast built to counterattack. Nausea, vomiting, hypoglycemia, contractions, eventually hemorrhages and premature birth are common.

In that sense, fertility clinics are forcing mother nature to bypass her natural defenses and makes things happen regardless of consequences.

The conditions of the fetus growing would mainly depend on this primitive and original incompatibility between parents, always present, always dangerous, being an invisible enemy. It could delay the optimal growth of fetus, disturb the neuro-psychic integrity or cognitive abilities, and even more so with the male child.

Bibliography
- An immunoreactive Theory of Selective Male Affliction, par Thomas Gualtieri et Robert E. Hicks, The Behavioral and Brain Sciences, 1985, 427-441.
- Antibodies to trophoblast in normal pregnant and secondary aborting women, par Kajino T, et ass. J Reprod Immunol 1988 dec.
- Detection of Maternal Antibodies In Infantile Autism, par R.P.Warren, p.Cole et ass., J. Am.Acad.Child Adol. Psychiatry, 29:6, November 1990 .
- Immunogenetic approaches to the analysis of mammalian development, par Heyner S., Dev Biol (N Y 1985);4:335-52.
- Immunologie fondamentale et Immunopathologie, par C.Griscelli, J.Paupe, C. Ponvert, Hôpital Necker, . éditions Ellipses, 1985, pages 85-86.
- Maternal immune response to pregnancy, par Billington WD, Reprod Fertil Dev 1989, discussion 191.
- Prognosis of the very low birthweight baby in relation to gender, par M. Brothwood, D. Wolfe, et ass., Archives of Disease in Childhood, 1986, 61, 559-564.
- Sex Differences in the Hyperkinetic Syndrome of Childhood, par A. James et E. Taylor, Journal of Child Psychiatry, 1989.
- Specific diversity in the immunogenetic relationship between mother and fetus, par Billington WD, Exp Clin Immunogenet 1993; 10(2):73-84.

Research

Claude Jolicoeur, pédopsychiatre, Montréal,
1997-2007
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